Метод НПТЭГ на 27ом Международном конгрессе Европейского респираторного общества
Доклад «Hemostatic potential evaluation of patient with COPD by low-frequency piezoelectric thromboelastography» (Оценка гемостатического потенциала пациента с ХОБЛ с помощью метода низкочастотной пьезотромбоэластографии) был представлен в Милане (Италия) на 27ом Международном конгрессе Европейского респираторного общества Брагиной Еленой Юрьевной (НИИ Медицинской генетики Томского НИМЦ) 9-13 сентября 2017го года.
Hemostatic potential evaluation of patient with COPD by low-frequency piezoelectric thromboelastography.
One of the main non-respiratory functions of the lungs is participating in regulation of hemostasis. Development and progression of COPD affects on coagulation and anticoagulation systems, leads to thrombosis.
The aim of our research is evaluation of hemostatic potential of patients with COPD in comparison with healthy volunteers. The research involved 10 smoking patients with COPD and 10 healthy non-smoking volunteers. Evaluation of hemostasis system was carried out using low-frequency piezoelectric thromboelastography (LPTEG), before smoking one cigarette and after. This method of thromboelastography allows us to perform realtime snapshot analysis of all components of hemostasis in patient whole blood.
Healthy volunteers did not have obvious defects of hemostatic potential before smoking. All patients with COPD had hypercoagulable type of hemostatic potential characterized by increased thrombin activity, and marked activation of anticoagulation and fibrinolysis. Hypercoagulation at all stages of hemostasis was observed after one time smoking of healthy volunteers. Whereas patients with COPD had thrombin activity increased in 1.2 in comparison before smoking one cigarette and 1.8 in comparison with healthy volunteers. A shift to hypercoagulation of the hemostatic potential was detected for 10 % of healthy volunteers and 10 % of patients with COPD after smoking of one cigarette.
Low-frequency piezoelectric thromboelastography allows to determine defects of hemostatic potential by patient with COPD and to perform monitoring of changes in the hemostatic potential.